5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula

Abstract  A polyethylenic fatty ester was isolated from the marine sponge Chondrilla nucula. The structure was elucidated through NMR spectral data and MS analysis as 5,9,23-triacon-tatrienoic methyl ester 1. Compound 1 is an elastase inhibitor [ID50=10 μg/mL (2·10−5M)].